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vraylar negative symptoms
Health TopicsSymptoms

Vraylar Negative Symptoms and How can you Manage them?

by Healthlinear
written by Healthlinear

Before we can talk about the vraylar negative symptoms, we should know what this drug is about. Vraylar is one of the most commonly prescribed antipsychotic drugs; as stated before, this is a prescription-only drug. You can buy it from a pharmacy without a prescription. The active ingredient which is responsible for the antipsychotic effect in this medicine is Cariprazine. Cariprazine is mainly used to treat bipolar depression, bipolar mania, and schizophrenia. This is also used along with other medicines in major depressive disorder.

How does Cariprazine work

Cariprazine work by acting on the d3 receptors and partially on the D2 receptor. This drug act as an agonist on this receptor but is selectively a D3 receptor agonist. This also acts on the serotonin 5-Ht1A as an agonist and stops the serotonin 5-HT2B receptor's function. Working on these receptors, cariprazine will control the psychosis.

Vraylar negative symptoms

With every drug, there are some side effects, and vraylar side effects are very common. Some of the vraylar negative symptoms are very serious, causing you to stop the medication. In contrast, the others can be dealt with. Following are some of the vraylar negative symptoms that you may experience.

Weight gain is quite common with antipsychotic drugs and is one of the vraylar negative symptoms.

Dizziness, lightheadedness, nausea, and drowsiness are also reposted in some of the cases. You might feel sleepy a lot which is the purpose of most antipsychotic drugs.

Suppose you have any of the serious side effects occurring like fainting or trouble breathing. In that case, you should contact your doctor right away.

If you already have diabetes, you are at the chance of facing one of the vraylar negative symptoms, which is the raised blood glucose levels. So, while taking this medicine, you need to keep your blood glucose levels in check.

A neuroleptic malignant syndrome is one of the vraylar negative symptoms as well, so report right away if you feel stiffness in your muscles or you are having severe pain in your muscles.

Tardive dyskinesia may also report as a result of this medication, and that is due to increased dopamine levels in your body. So, if you feel uncontrolled movement, get back to your doctor.

How can you control these Vraylar negative symptoms?

When you are taking your medication to the dose prescribed by your doctor, you are less likely to experience these vraylar negative symptoms.

  • You should start with a low dose as directed by your doctor to control these sudden side effects. If required, the dose will only be increased by your doctor
  • Don’t try to take too much if it isn’t working for the first few days. Most people take more than they have been prescribed when medicines don’t work, leading to an overdose.
  • Try taking medicine at the same time every day so that the previous one is out of your system when you are taking your next dose.
  • When you need to stop the medication, the dose is decreased slowly first, so don’t try it yourself, or else you will feel withdrawal.
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Ibuprofen & Bactrim
Pain ReliefSymptomsUncategorized

Can you take Ibuprofen with Bactrim?

by Healthlinear
written by Healthlinear

Ibuprofen and Bactrim are two different kinds of medications, however many people wonder if they can take ibuprofen with Bactrim or not. Simply when you are using two different medications, you should know if there are possible adverse effects of using both these drugs together or not. Then there are also drug interactions that you should watch out for as they can increase or decrease the absorption of the other drug.

Bactrim Oral

Bactrim is the combination of two antibacterial drugs known as trimethoprim and sulfamethoxazole. Both of them are generic antibiotics. Both these drugs act together to stop and prevent intestinal, urinary, respiratory, and middle ear infections. Even though this drug is used for these infections, you should only b taking it on the advice of your doctor. These drugs are prescription-only because misuse of such medications can lead to resistance in the patients. When the Bactrim DS is prescribed to you should take it regularly for the prescribed period, and the prescribed dose should be taken as well to avoid any complications.

Ibuprofen

Ibuprofen is an over-the-counter medicine. Due to this reason, this question about whether can you take ibuprofen with Bactrim or not is acknowledged. The ibuprofen is an anti-inflammatory drug, and it also controls the pain in your body by activating certain enzymes. This is the most commonly used painkiller, and it is also used in fever.

Can you take Ibuprofen with Bactrim together

The Bactrim and ibuprofen can be taken together when your doctor prescribes you. he does it because he has your best interest in mind. Usually, both are given together because patients can experience fever and pain in an infection. When two drugs are taken together, they may alter the effect of each other. This causes a change in the expected result of the drug.

Usually, if the drug interaction is too severe, then the pharmacist will advise you against using these medications together. If anything, you can take a gap between each of the medications as well. When it comes to Bactrim and ibuprofen, there is only one minor drug interaction between these two. The drug interaction that is caused is because of the ibuprofen. This drug will increase the effect and absorption of Bactrim. This effect is not bothersome at all, but you can use it as per the instructions of your doctor and pharmacist.

Avoiding the adverse effect after taking Ibuprofen with Bactrim

Now your question of whether can you take ibuprofen with Bactrim or not has been answered. You should know how you can avoid this interaction from happening completely. If the drugs have been prescribed by your doctor, then you can continue taking them together; the interaction is minor. But otherwise, you can give some gap between these two medications.

Since it is the metabolism of the Bactrim that will be altered, you can take almost an hour gap between these two medications. If you have to take them together, then you can do that as well. Make sure to show compliance with your doctor’s prescription. You can also go for other drugs like acetaminophen with Bactrim instead of ibuprofen.

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Megapophobia Symptoms
Symptoms

Megalophobia and What are its Signs and Symptoms

by Healthlinear
written by Healthlinear

Megalophobia, by definition, is a fear of large buildings, vehicles, or any object that is bigger. In some people, the condition is so severe that they are unable to perform daily life activities just because anything they encounter is bigger than the normal size. In this way, you will be nervous about going into large buildings, and it invokes a certain kind of fear in you that stops you from going into such a building and traveling in planes, etc.

Psychology behind megalopolis

Phobia is usually considered as the fear against something, which, in reality, is anxiety-related to something this may not be harmful in real life vet the anxiety can stop the person from doing things or being near things, they are afraid of. All of this happens because of their anxiety. The difference between phobia and fear is that you may e able to overcome your phobia, but phobia itself can transform into fear, causing you unable to do your regular activities. The reason behind such phobias can be some events or just anxiety over certain things, with megalophobia most of the time it is because of the bad experience faced by a large object.

Symptoms of megalophobia

Phobia of any kind and usually have similar symptoms that different stimulus triggers. Following are some of the symptoms that you will experience in megalophobia

  • Sweating
  • Dizziness
  • Vomiting and diarrhea
  • Shortness of breath
  • Panic attack
  • Crying
  • Shaking
  • Raised heart rate
  • Chest pain
Megalophobia Symptoms

These are all the symptoms you will experience in any kind of phobia, including megalophobia as well.

What triggers megalophobia

Usually, the megalophobia is a fear of big objects, but there is the various thing that can set off the phobia in the people and following are some of those causes

  • In transport, it includes airplanes, helicopters, and big truck and buses as well
  • Large animals or sea creatures might also invoke this fear, and those include the whales, elephants, and giraffes as well.
  • Some big statues and monuments may also seem approachable by certain people, and it is very hard to be around them.
  • Boats, yachts, and ships are also responsible for setting off megalophobia in a person.
  • High things are not the only reason the things like large lakes and the ocean itself can cause a person to experience megalophobia as well.
  • Big spaces where you might feel claustrophobic can also be named megalophobia.
  • Such people may also get scared of huge mountains and hills and are never able to climb them.
  • Buildings are for sure one of the things that cause megalophobia. It's not all buildings but the huge ones, including the skyscrapers.

Diagnosis

When it comes to diagnosis of megalophobia but it is evaluated by your psychiatrist. You are evaluated based on your past experiences and recalling an event that started it. Some people are not even aware of the fear of there until it is diagnosed by a psychiatrist. With all this information, they try to reach the root cause of your problem. One diagnostic test can be used, and that is by the images. The medical examiner shows you certain pictures of the things they are suspecting you might be afraid of. Once they goad your reaction with certain images, they diagnose the type of phobia you have. Once a proper diagnosis has been made, a treatment plan is made afterward.

Treatment of megalophobia

For the treatment of megalophobia, combination therapy can be used. This involves the medications to control your anxiety, and the other method is therapy to try to illuminate the root cause of fear; the decision to take medicines is made based on what is the extent of our fear you face by such stimulus. Following are the treatments used for megalophobia.

  • Cognitive behavior therapy is a treatment technique that turns your irrational fears into rational thoughts.
  • Talk therapy with a psychologist may help a lot.
  • Group therapy with people who have similar or almost similar fears may help a lot, and you all can overcome these fears together.
  • Exposure therapy may help, too, with the thought that you will face that thing, and nothing that happens will take the fear away from your mind.

The medications that may be used are as follows

  • Beta-blocker help control your anxiety by controlling heart palpitations.
  • Selective serotonin reuptake inhibitors will also control anxiety.
  • The Selective non-epinephrine reuptake inhibitors perform the same role.

This is all you needed to know.

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wellbutrin and alcohol
DepressionSymptoms

Interactions and Side Effects of Using Wellbutrin and Alcohol Together

by Healthlinear
written by Healthlinear

Wellbutrin and alcohol, when consumed together, put the patient at high risk for serious health impairments, nausea, vomiting, and seizures. We know that antidepressant medication is an important tool for people who struggle with depression and anxiety on a daily basis. As is the case with all drugs, most antidepressants can have certain dangerous side effects if consumed with alcohol. Wellbutrin is one such antidepressant that interacts dangerously with alcohol.

What is Wellbutrin?

Wellbutrin is the brand name of the generic drug Bupropion. It is a prescription drug used to treat different types of clinical depression. Wellbutrin is a norepinephrine-dopamine reuptake inhibitor (NDRI). It is usually prescribed to people who don’t respond well to other antidepressant medication. It is available in different tablet forms, including extended-release (XL), sustained-release (SR), and immediate-release (IR) variations.

Wellbutrin is an FDA (Food and Drug Administration) approved treatment for major depressive disorder (MDD) and seasonal affective disorder (SAD), also known as “winter depression”. Wellbutrin is distinctive from other antidepressants because it doesn’t affect your weight, libido and sexual desires as some other antidepressants are wont to do. Because of this quality, Wellbutrin is often prescribed in combination with other antidepressants to help counteract the side-effects that affect sexual desire.

Off-Label Uses for Wellbutrin:

While the FDA approved use for Wellbutrin is to treat MDD and SAD, wellbutrin is frequently prescribed off-label to alleviate the symptoms of attention-deficit/hyperactivity disorder (ADHD), anxiety, bipolar disorder, and obesity. It can also be used to help people quit smoking. Furthermore it can help with PTSD, social anxiety disorder, and nerve pain.

Interactions of Wellbutrin with other medication:

As with other drugs, there are potential interactions that may occur when Wellbutrin is taken at the same time as other substances. Some medications that increase the risks of side effects include:

  • Antipsychotics
  • Blood thinners
  • Corticosteroids
  • Thyroid medications
  • Monoamine oxidase inhibitors
  • OTC pain relievers such as ibuprofen
  • Amphetamine and dextroamphetamine
  • Diabetes medications including metformin
  • Other antidepressants including Prozac, Zoloft, and Effexor

Interaction of Wellbutrin with Alcohol:

Wellbutrin and alcohol have a complicated relationship. Even though some people can drink occasionally without side-effects while on Wellbutrin, abusing alcohol regularly while you are on Wellbutrin can have seriously adverse effects on your health. If you are not a frequent or regular drinker, drinking alcohol while you are on Wellbutrin can induce side effects like seizures and having suicidal thoughts. On the other hand, heavy drinkers may also experience seizures if they abruptly stop imbibing while on Wellbutrin.

Some known risks of mixing Wellbutrin and alcohol:

  • Nausea
  • Fatigue
  • Seizures
  • Paranoia
  • Vomiting
  • Blackouts
  • Dizzy spells
  • Blurred vision
  • Poor judgment
  • Suicidal thoughts
  • Alcohol poisoning
wellbutrin and alcohol

Long-Term Effects Of Mixing Alcohol And Wellbutrin

Alcohol should be used cautiously, but even more so for people battling depression. Alcohol is a natural depressant. Mixing alcohol with Wellbutrin increases the side effects of both Alcohol and Wellbutrin, and it also increases the likelihood of developing an unhealthy dependence or addiction to alcohol.

Combining Wellbutrin and alcohol regularly can have long-term effects including:

  • Increased overdose risk
  • Increased risk of alcohol addiction
  • Decreased Wellbutrin effectiveness

If you take Wellbutrin and want to know how it will interact with alcohol, consult your doctor and discuss your alcohol habits truthfully. Wellbutrin is not the only antidepressant that is not supposed to be taken with alcohol. It is highly inadvisable to consume Lexapro and Alcohol together. You should consult your doctor before making any changes in your drinking routine.

FAQs:

Is it safe to drink alcohol while taking Wellbutrin?
Short answer, No. Long answer, still no. It can cause suicidal thoughts and tendencies and cause more depression.

Can Wellbutrin cause personality changes?
Wellbutrin may cause some people to become nervous, ill-tempered, agitated, and display other abnormal behavior.

How much weight can you lose on Wellbutrin?
Weight loss is a purported side effect of Wellbutrin but the reasons may not be directly related to the drug. Studying the correlation of Wellbutrin and weight change Both weight loss and weight gain have been observed.

Does Wellbutrin increase your sex drive?
Wellbutrin has a positive impact on libido, but it does not cause hypersexuality.

Does Wellbutrin help you focus?
Wellbutrin is a norepinephrine and dopamine reuptake inhibitor (NDRI). It operates by keeping the neurotransmitters norepinephrine and dopamine available to your brain's neurons for longer. This helps improve concentration, focus, and other ADHD symptoms.

Will Wellbutrin help me sleep?
The antidepressant Wellbutrin (bupropion) is linked to insomnia. However, studies examining the electrical activity in the brain of patients taking bupropion indicate that the drug actually increases REM sleep time.

References:

Fava, Maurizio et al. “15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL.” Primary care companion to the Journal of clinical psychiatry vol. 7,3 (2005): 106-13. doi:10.4088/pcc.v07n0305
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1163271/

Grover, Sandeep, and Partha Pratim Das. “Can bupropion unmask psychosis.” Indian journal of psychiatry vol. 51,1 (2009): 53-4. doi:10.4103/0019-5545.44907
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738405/

Karam-Hage, Maher et al. “Bupropion-SR for smoking reduction and cessation in alcohol-dependent outpatients: a naturalistic, open-label study.” Current clinical pharmacology vol. 9,2 (2014): 123-9. doi:10.2174/1574884708666131112124429
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056335/

Schramm, Preetam J et al. “Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk.” European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 24,2 (2014): 207-14. doi:10.1016/j.euroneuro.2013.09.007
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948318/

Hill, Stanley et al. “A case report of seizure induced by bupropion nasal insufflation.” Primary care companion to the Journal of clinical psychiatry vol. 9,1 (2007): 67-9. doi:10.4088/pcc.v09n0114a
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1894833/

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