Qelbree vs Strattera: Unveiling the Choices in ADHD Management

Let’s have a look at the differences between Qelbree vs Strattera. To put it briefly, Qelbree is a non-stimulant targeting emotional dysregulation, while Strattera enhances attention through norepinephrine reuptake inhibition in ADHD treatment.

Attention Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental condition that affects millions of individuals worldwide, both young and old. This article aims to provide a comprehensive and detailed comparison between two notable medications, among others, used in managing ADHD—Qelbree and Strattera. By exploring various aspects of these medications, we seek to empower patients and caregivers with the information needed to make informed decisions about their ADHD treatment journey.

Understanding ADHD and its Multifaceted Treatment Approaches

ADHD is characterized by persistent symptoms of inattention, hyperactivity, and impulsivity that can significantly impact various aspects of an individual’s life. While behavioral therapies and lifestyle adjustments play a crucial role in managing ADHD, medications such as Qelbree and Strattera offer pharmacological interventions to complement these strategies.

Qelbree: A Novel Non-Stimulant Approach to ADHD Management

Qelbree represents a newer approach to ADHD management. Unlike traditional stimulant medications, Qelbree is classified as a non-stimulant and operates through a mechanism involving certain brain receptors related to mood and behavior regulation. By targeting these receptors, Qelbree aims to provide a unique pathway for managing emotional dysregulation and impulse control often seen in individuals with ADHD.

Strattera: Enhancing Norepinephrine for Improved Focus and Control

Strattera takes a distinct route in treating ADHD. As a norepinephrine reuptake inhibitor, Strattera works by increasing the levels of norepinephrine—a neurotransmitter associated with attention and focus. By enhancing norepinephrine activity, Strattera aims to improve attention control and potentially mitigate hyperactivity and impulsivity in individuals with ADHD.

Qelbree vs Strattera: Comparing Efficacy

Qelbree’s Efficacy

Qelbree, a novel non-stimulant medication, has demonstrated effectiveness in managing ADHD symptoms, particularly in controlling emotional dysregulation and impulsivity. Clinical studies have shown that Qelbree can lead to significant reductions in ADHD symptoms, as measured by standardized rating scales. Its unique mechanism of action, targeting specific brain receptors related to mood and behavior, offers an alternative treatment option for individuals who may not respond well to stimulant medications.

Strattera’s Effectiveness

Strattera, a norepinephrine reuptake inhibitor, has also shown efficacy in improving ADHD symptoms. By increasing norepinephrine levels, Strattera enhances attention control and focus, making it a valuable option for individuals seeking non-stimulant alternatives. Clinical trials have demonstrated its ability to reduce inattentiveness, hyperactivity, and impulsivity, contributing to better overall functioning.

Both Qelbree and Strattera have demonstrated efficacy in reducing ADHD symptoms. However, individual responses can vary significantly. Factors such as genetics, underlying brain chemistry, and coexisting conditions contribute to the variability in treatment outcomes. Collaborating closely with healthcare providers is key to tailoring treatment plans for optimal results.

Qelbree vs Strattera: Mechanisms of Action

Qelbree’s mechanism of action involves modulating specific neurotransmitter receptors, resulting in the regulation of emotions and behaviors. Strattera, in contrast, focuses on increasing norepinephrine levels, which in turn influences attention and impulse management. Understanding these mechanisms assists healthcare professionals in tailoring treatment strategies to individual needs.

Qelbree vs Strattera: Unmasking Potential Side Effects

Qelbree’s Potential Side Effects

  • Qelbree, as a non-stimulant medication for ADHD, may have the following potential side effects:
  • Drowsiness: Some individuals may experience drowsiness or fatigue, particularly during the initial stages of treatment.
  • Irritability: Mood changes, including irritability or mood swings, have been reported as possible side effects.
  • Decreased Appetite: Qelbree could lead to a reduced appetite in some patients, which might impact eating habits.
  • Insomnia: While not as common as with stimulant medications, Qelbree might cause difficulties in falling asleep or maintaining sleep.

Strattera’s Potential Side Effects

Strattera, as a norepinephrine reuptake inhibitor, may come with the following potential side effects:

  • Nausea: Nausea is one of the common side effects reported with Strattera, especially during the initial period of usage.
  • Dry Mouth: Some individuals may experience dry mouth, which can be managed by staying hydrated and using sugar-free gum or lozenges.
  • Mood Changes: Strattera might lead to changes in mood or emotional sensitivity in some patients.
  • Upset Stomach: Individuals might experience stomach discomfort or upset as a side effect.
  • Fatigue: Strattera could cause feelings of tiredness or fatigue, affecting energy levels.

It’s important to note that individual responses to medications can vary, and not everyone will experience these side effects.

Qelbree vs Strattera: Dosage and Administration

Qelbree is typically administered once daily, with or without food. Strattera, too, is taken once daily, preferably in the morning to minimize potential sleep disruptions. Determining the appropriate dosage requires consideration of factors such as age, weight, and individual response.

Long-Term Effects and Considerations

The long-term effects of Qelbree and Strattera are subjects of ongoing research. Regular follow-ups with healthcare providers are essential to monitor progress and address any emerging concerns. Individual responses to these medications may evolve over time, underscoring the need for consistent medical oversight.

Qelbree vs Strattera: Children and ADHD Medications

Both Qelbree and Strattera are approved for pediatric use. Qelbree’s approval varies across specific age groups, while Strattera is sanctioned for children aged 6 and above. Pediatric treatment decisions involve careful consideration of potential benefits and risks, emphasizing the importance of collaboration between parents, caregivers, and healthcare providers.

Qelbree vs Strattera: Examining Compatibility with Other Drugs

It’s essential to disclose all medications, including supplements and herbs, to healthcare providers before beginning Qelbree or Strattera. Potential interactions can impact the efficacy and safety of these medications, making accurate information crucial for personalized treatment.

Qelbree’s Interactions with Other Drugs

Qelbree, a non-stimulant medication for ADHD, may interact with the following substances:

  • Alcohol: Combining Qelbree with alcohol may increase the risk of drowsiness and impaired judgment. It’s advisable to avoid alcohol while taking Qelbree.
  • Central Nervous System Depressants: Drugs that have a depressant effect on the central nervous system, such as sedatives or tranquilizers, might enhance the sedative effects of Qelbree.
  • CYP3A4 Inhibitors: Some medications that inhibit the CYP3A4 enzyme in the liver might affect the metabolism of Qelbree, potentially altering its effectiveness or concentration in the body.
  • Medications that Cause Drowsiness: Combining Qelbree with other medications that cause drowsiness, such as antihistamines or sleep aids, may amplify the sedative effects.
  • Monoamine Oxidase Inhibitors (MAOIs): Qelbree should not be taken concurrently with MAOIs due to the risk of serious adverse reactions.

Strattera’s Interactions with Other Drugs

Strattera, a norepinephrine reuptake inhibitor, might interact with the following substances:

  • Monoamine Oxidase Inhibitors (MAOIs): Strattera should not be taken with MAOIs due to the risk of severe adverse effects.
  • Blood Pressure Medications: Strattera might influence blood pressure, so combining it with blood pressure medications could potentially lead to interactions. Close monitoring is advised.
  • Medications that Affect Heart Rate: Drugs that impact heart rate or rhythm, such as beta-blockers, might interact with Strattera. Monitoring heart health is crucial in such cases.
  • CYP2D6 Inhibitors: Strattera is metabolized by the CYP2D6 enzyme. Medications that inhibit this enzyme might affect Strattera’s metabolism and concentration in the body.
  • Certain Antidepressants: Some antidepressants, especially selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), could interact with Strattera. Consultation with a healthcare provider is recommended.

Qelbree vs Strattera from a Financial Perspective

The cost of medication is a pivotal factor in treatment decisions. Generic options, might offer a more cost-effective solution for some patients compared to the brand names. A month supply of Qelbree will cost around $400 while for Strattera this goes to about $450. However, financial considerations should be balanced with treatment efficacy and individual preferences.

Qelbree vs Strattera: Pros and Cons



  • Non-Stimulant Approach: Qelbree offers a non-stimulant treatment option for ADHD, making it suitable for individuals who do not respond well to or prefer to avoid stimulant medications.
  • Targeting Emotional Regulation: Qelbree’s mechanism of action focuses on mood and behavior regulation, which can be beneficial for individuals with ADHD who struggle with emotional dysregulation.
  • Unique Pathway: Qelbree provides a novel approach to managing ADHD symptoms, addressing emotional aspects that stimulant medications may not target as effectively.
  • Potential for Reduced Abuse: As a non-controlled substance, Qelbree might have a lower risk of abuse compared to stimulant medications.


  • Side Effects: Qelbree can lead to side effects such as drowsiness, irritability, and decreased appetite.
  • Limited History: Being relatively new, Qelbree’s long-term effects and effectiveness over extended periods are still being studied.
  • Individual Variability: Efficacy varies among individuals, and some may not experience substantial improvements in ADHD symptoms.



  • Non-Stimulant Option: Similar to Qelbree, Strattera provides a non-stimulant alternative for ADHD treatment, catering to those who cannot tolerate stimulants.
  • Attention Enhancement: Strattera’s focus on increasing norepinephrine levels enhances attention control, potentially aiding individuals with difficulties in focusing.
  • Approved for Children and Adults: Strattera is approved for both pediatric and adult use, providing a consistent treatment option across age groups.
  • Longer-Lasting Effect: Strattera’s effects can last throughout the day, without the need for multiple doses.


  • Side Effects: Strattera can lead to side effects such as nausea, dry mouth, mood changes, and fatigue.
  • Delayed Onset: It may take several weeks for Strattera to reach its full therapeutic effect, requiring patience during the initial phase of treatment.
  • Interactions: Strattera might interact with other medications, particularly those that affect heart rate or blood pressure.
  • Limited Immediate Impact: Unlike stimulant medications, Strattera might not provide an immediate noticeable improvement in symptoms.

In considering the pros and cons of both Qelbree and Strattera, it’s essential to consult with a healthcare provider to determine the most suitable treatment based on individual needs, preferences, and medical history

Qelbree vs Strattera: Making Informed Decisions

Choosing between Qelbree and Strattera requires a holistic approach that considers individual response, medical history, lifestyle, and treatment goals. Collaborating closely with healthcare providers empowers patients and caregivers to make decisions aligned with the unique needs of the individual.

AspectQelbree              Strattera
Type of MedicationNon-stimulant  Non-stimulant  
Mechanism of ActionMood and behavior regulation  Norepinephrine reuptake inhibition
Target SymptomsEmotional dysregulation, impulsivity         Inattention, hyperactivity, impulsivity
Abuse RiskLow (non-controlled substance)Low (non-controlled substance)
Approved AgesSpecific age groups         Children (6+) and adults
Potential Side EffectsDrowsiness, irritability, decreased appetite        Nausea, dry mouth, mood changes, fatigue
Time to EffectWeeks Weeks 
InteractionsCYP3A4 inhibitors, CNS depressants      Heart rate/blood pressure medications
Long-term EffectsOngoing research           Ongoing research           

The Medical Perspective on ADHD Medication Choice

Medical experts often lean towards initiating treatment with stimulant medications due to their established track record. However, Qelbree and Strattera offer valuable alternatives, especially for individuals who may not respond well to stimulants or experience intolerable side effects.

Qelbree vs Strattera: Conclusion

In the realm of ADHD treatment, the choice between Qelbree and Strattera reflects a broader philosophy of tailoring treatment to the individual. Both medications contribute distinctively to managing symptoms and improving daily functioning. Ultimately, the decision hinges on informed choices, collaboration with healthcare providers, and ongoing evaluation.

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Qelbree vs Strattera: FAQs

Why is Qelbree better than Strattera?

The choice between Qelbree and Strattera depends on individual preferences and treatment goals. Qelbree’s unique mechanism targeting mood and behavior regulation might be preferred for those with emotional dysregulation. Strattera, on the other hand, enhances attention control. Consulting a healthcare provider is crucial to determine which medication aligns better with your specific ADHD symptoms and needs.

What is better than Strattera?

The “better” choice between ADHD medications varies from person to person. Qelbree, for instance, offers a different approach by targeting emotional aspects, while other non-stimulant options like Intuniv or Kapvay focus on different pathways. The most suitable choice depends on your symptoms, medical history, and response to treatment.

What is the best non-stimulant ADHD medication?

There isn’t a one-size-fits-all answer. Qelbree, Strattera, Intuniv, and Kapvay are some non-stimulant options. The best choice depends on your individual needs, response to medications, and potential side effects. Collaborating with a healthcare provider helps determine the most effective treatment.

Is Qelbree as effective as Adderall?

Qelbree and Adderall are distinct medications with different mechanisms. Adderall is a stimulant, while Qelbree is a non-stimulant. Their effectiveness depends on the individual’s symptoms and response. Qelbree may be preferable for those who don’t respond well to stimulants or have certain side effect concerns.

What is the most successful ADHD medication?

Success varies among individuals. Stimulant medications like Adderall and Ritalin have a long history of effectiveness, but newer options like Qelbree and Strattera offer alternatives. The most successful medication is the one that effectively manages symptoms with minimal side effects for each individual.

What is the safest most effective ADHD medicine?

Safety and effectiveness depend on individual factors. Stimulant medications are often effective but come with potential side effects. Non-stimulants like Qelbree and Strattera offer alternatives. The safest and most effective medication is determined through consultation with a healthcare provider.

What is the downside of Strattera?

The downsides of Strattera may include potential side effects such as nausea, dry mouth, mood changes, and fatigue. It may also take weeks to achieve its full effect. Additionally, individual responses vary, and Strattera might not provide immediate symptom relief like stimulants.

Is Strattera the best ADHD medication?

Strattera is a valuable ADHD medication, but “best” depends on individual needs. Strattera is a non-stimulant option that enhances attention control. Other factors like side effect profile, response, and medical history should be considered when determining the best medication.

What is the black box warning on Strattera?

Strattera carries a black box warning regarding an increased risk of suicidal thoughts and behavior, particularly in children and adolescents. It’s important for healthcare providers and caregivers to closely monitor individuals taking Strattera, especially at the beginning of treatment.

What are the side effects of Qelbree in children?

Qelbree’s side effects in children may include drowsiness, irritability, and changes in appetite. Like with any medication, individual responses vary. If side effects are concerning or persistent, consult a healthcare provider.

Does Strattera help with anxiety?

Strattera’s primary focus is on ADHD symptoms, but some individuals report improvements in anxiety symptoms. However, it’s not specifically indicated for anxiety treatment. Consultation with a healthcare provider is essential to address both ADHD and anxiety concerns.

Does Strattera make you gain weight?

Weight changes are possible with Strattera, but they don’t occur in everyone. Some individuals might experience weight gain, while others may not see any significant changes. Monitoring weight and discussing any concerns with a healthcare provider is recommended.

What are the positive effects of Qelbree?

Positive effects of Qelbree may include improved emotional regulation, reduced impulsivity, and enhanced focus. It offers a unique approach to ADHD management by targeting mood-related aspects of the condition.

Does Qelbree cause weight gain or loss?

Qelbree can potentially cause weight loss due to decreased appetite as a side effect. However, not everyone experiences this effect. Individual responses vary, and it’s important to communicate any weight-related changes to your healthcare provider.

Will Qelbree cause weight loss?

Weight loss is a potential side effect of Qelbree due to decreased appetite. However, the extent of weight loss varies among individuals. If you have concerns about weight changes, consult your healthcare provider.


  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).
  • Armstrong, T. (2010). The Power of Neurodiversity: Unleashing the Advantages of Your Differently Wired Brain. Da Capo Press.
  • Cortese, S., & Castellanos, F. X. (2012). Neuroimaging of attention-deficit/hyperactivity disorder: Current neuroscience-informed perspectives for clinicians. Current Psychiatry Reports, 14(5), 568-578.
  • National Institute of Mental Health. (2020). Attention Deficit Hyperactivity Disorder. https://www.nimh.nih.gov/health/topics/attention-deficit-hyperactivity-disorder-adhd/index.shtml
  • Adler, L. A., & Nierenberg, A. A. (2010). Review of medication adherence in children and adults with ADHD. Postgraduate Medicine, 122(1), 184-191.

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