Oxycodone vs Hydrocodone

Oxycodone vs Hydrocodone

Before we don in the detailed discussion of oxycodone vs hydrocodone we should know in detail what oxycodone and hydrocodone are and all about them. Both of these are the pain relief drugs that are the prescription-only drugs.  By prescription only drugs we mean the type of drugs that can be bought only when prescribed by the health practitioner himself. Even being only the pain relieving medicines oxycodone and hydrocodone are still the prescription-only medicines and the reason why is that they are used to relieve the pain in some specific conditions and diseases like a chronic cough, cancer, and arthritis. Both of these drugs are used for the treatment of chronic or long-term pain. Both of these drugs can be taken only with the prescription.

Oxycodone vs hydrocodone – The Introduction

Oxycodone and hydrocodone both are the narcotic analgesics. Narcotics are those painkillers that are the opioid derivatives. Oxycodone is the semisynthetic opioid that is synthesized from the opioid alkaloid thebaine found in the Persian poppy plant. Hydrocodone, on the other hand, is the semisynthetic too and is synthesized from the opioid codeine and it is also known as dihydrocodeine and it is also obtained from the Persian poppy plant.


Both of these drugs have almost the same mechanism of action for the pain relief. They bind to the opioid receptor and inhibit the adenylyl-cyclase and also inhibit the hyperpolarization of neuron which results in the inhibition of the excitation of the neurons and thus there is the relief of the pain. In short, both of these drugs inhibit the pain signals to reach the brain. Both of these drugs bind to the mu opioid receptors which result in a relief of pain.

Both of these drugs can be given alone and also in the combination but there is a difference between the oxycodone vs hydrocodone can be combined with the acetaminophen which is another painkiller and the combined effect thus helping the patient to relax until the painkiller starts working while the hydrocodone can be combined with the antihistamines to create a syrup that can be used to reduce or suppress a cough and it also helps to achieve the relief from the cough pain.

Drug class of these drugs

Oxycodone and hydrocodone both of these drugs belong to the narcotic analgesic class of drug while in the completely different context of being misused they belonged to two different schedules. The oxycodone vs hydrocodone was on a different schedule but that lasted only until 2014 when both the drugs were placed on the same schedule. They are counted in the schedule II drugs now according to which they both have the tendency to be misused. This schedule indicates the potential of being misused as well as the medicinal use of these compounds and the oxycodone and hydrocodone lie in the schedule II.

Drug Dosage

Drug dosage and the form is another thing that can help with the comparison of oxycodone versus hydrocodone. Even though both of these drugs belong to narcotics analgesic class but still their dosing regime and form can be a little or entirely different from each other. Oxycodone vs hydrocodone is available in the form of the tablets that can be prescribed by the doctor to be taken every 12 hours and these tablets come in different doses and the dose is selected based upon the extent of pain the patient is going through and on the other hand the hydrocodone comes in the extended release form which means it will be absorbed into your blood really slow to provide your body with constant and continuous dose of the drug.

And another form of hydrocodone is also available that can be taken after every 12 hours and that dosage for is the capsules but if you are not keen on the idea of taking medication after 1 hour then you should go for the extended release type of drug dosage form. So this is a little point to support the oxycodone vs hydrocodone argument that gives you a reason to select the type of medication based on what you feel comfortable to use.


Ignoring every other thing the main thing that usually people focus upon is the effectiveness of the drug and they are likely to go for the one that is more effective. Buy in this case there is no such strong proof to support the oxycodone vs hydrocodone argument because the studies have shown that both of these drugs relieve pain the exact same way and the effectiveness is same too.

Both of these drugs are used to release a high degree of pain experiences in fractures etc. and the effect of both of the drugs start after 30 minutes. But some studies have shown that people who used hydrocodone had to suffer from constipation more frequently than the oxycodone and also that oxycodone vs hydrocodone when combined with acetaminophen, was 1.5 times more effective.

Side effects

The side effects of both of these drugs just like their effect are quite similar and following is the list of some of the side effects of both of these drugs.

  • Drowsiness
  • Nausea
  • Vomiting
  • Itchiness
  • Lethargy
  • Motor skill impairment
  • Shallow breathing
  • Dry mouth

Side Effects of Oxycodone vs Hydrocodone

Both of these drugs produce the same side effects but coming to the comparison it can be noticed that in oxycodone vs. hydrocodone, oxycodone is more likely produces side effects like lethargy, headache, euphoria, and dizziness while on the other hand hydrocodone is more likely to cause side effects like constipation and stomach ache. There are also some serious side effects observed by the use of these two drugs and those side effects are

  • Seizures
  • Pain while urination
  • Arrhythmia
  • Confusion etc.

So these were some of the similar as well as the different side effects that are observed by the use of oxycodone and hydrocodone.

Cost difference

The cost difference between these two drugs can also help us determine which drug to choose from the oxycodone vs hydrocodone. Hydrocodone is a little expensive than the oxycodone. The difference between the prices is quite a lot so you can choose the one that is less expensive if you are looking for economical treatment.


There are a lot of conditions in which both of these drugs are contraindicated like in the condition of asthma they should avoid taking these medications and in case of already existing constipation, you should avoid taking both of them but especially the hydrocodone which causes more constipation than the oxycodone.

Pregnant women are advised to discuss them with their doctors while in the nursing mothers both shouldn’t be used at all because it can pass through the breast milk and can enter in the baby’s body leading to serious consequences. So you should also avoid leaving pills within the reach of children because if ingested accidentally can cause harm to your baby.

So these were some of the differences and now its upon you which one you consider the better pain reliever for you and also you should discuss it with your doctor about how you feel comfortable about taking which one of the pills and so the doctor will guide you about what could be the better choice for you in oxycodone vs hydrocodone.

Zoloft and Alcohol

Zoloft and Alcohol Combination

Zoloft and Alcohol combination is never a good idea and this whole article is the explanation of all the reasons why these two drugs should not be taken together. Zoloft, as you all know, is a medicine that is prescribed by the health practitioners to the people suffering from depression. Depression is a psychological disorder that has been seeming to be increasing a lot since the past few years and it is most likely to be found among teenager.

Depression is something that keeps eating a person emotionally and most of the people going through it choose to end their life when the depression stays unaddressed so this is why it is important to address the needs of the people around us and in the whole society. Zoloft and other such medications are prescribed by the doctors in the depression but in some situations, even these medications fail to help the person and those such situations include mixing of Zoloft and alcohol.

Symptoms of depression

Depression is a very important issue in today’s society and the more we talk about it the less it is and we as an active member of our society should take part in spreading awareness about depression. Depression is one of the reasons the suicidal ratio increasing day by day.

When you are depressed you lose all the hope in your life and then you see no purpose of your life so you just decide the world is better off without you and this is exactly why we need to fight depression. Depression is most likely to occur in teens as compared to the adults and in females as compared to the males. Following are some of the symptoms of the depression

  • Helplessness or hopelessness
  • Changes in appetite and weight
  • Anger or irritability
  • Self-loathing and self-destructive attitude
  • Short attention span
  • Sleep changes and loss of interest in activities of life.

Side Effects of Depression

So these were some of the symptoms and if you see them in yourself then you should definitely visit a doctor.

What is the impact of alcohol and Zoloft in the depression?

Zoloft and Alcohol are two opposite drugs. Alcohol itself is a drug and it is one of those drugs that depress our central nervous system. Even though it activates our nervous system for a little while but then it starts depressing it and if the person is already suffering from the depression you can imagine what the intake of Alcohol can do to them. Zoloft versus Zahra is used as an antidepressant which shows that it has opposite of action.

Zoloft is basically the brand name of the generic drug known as the sertraline. Sertraline is the serotonin reuptake inhibitor and serotonin being a chemical that helps in elevation of your mood upon being blocked from the reuptake can help you get over your depression. So this is how the generic drug sertraline works in the form of capsule Zoloft.

Zoloft and alcohol

Zoloft and Alcohol should not be taken together because both of these drugs are the antagonist of each other. By antagonist to means that action of one drug will be the exact opposite of what other drug is doing and in such way, none of the drugs will be able to produce their action.

Since the situation, we are dealing here is depression we should definitely opt for the drug that helps to recover depression which in this case is Zoloft and not the one that further pulls you in the depression that in this case is the alcohol. The difference between both of these drugs is huge and this is exactly why they are not a perfect combination to be used together.

Drinking while you are in depression will pull you further into it so instead of doing that you should try to get yourself recovered from depression which has the potential to eat up your whole life and your career. If the person is already in a depression and the doctor has prescribed him with the Zoloft then according to U.S Food and Drug Administration guidelines you should not be taking Alcohol at all because then the purpose if your therapy will be futile otherwise.

So due to this type of interaction you should avoid the use of Alcohol at all, in fact, you shouldn’t even look at Alcohol when you already are in the depressed stage because the side effects in such cases are endless and the risk to the life is even greater then.


You must have heard of drug-drug interactions. There are two types of drug-drug interaction and that are synergistic or antagonist. Antagonist means the complete opposite of each other and Zoloft and alcohol has that kind of interaction with each other. Alcohol makes the potential side effects of the Zoloft even worse and they are as follows.

  • Dizziness,
  • A headache
  • Depression
  • Suicidal thoughts
  • Diarrhea etc.

So these symptoms can get elevated upon the combined use of Zoloft and Alcohol. So while you are on the medications like Zoloft you should avoid drinking beer or any other alcoholic beverages and this isn’t only because alcohol affects the activity of Zoloft it is also because Zoloft makes the effects of Alcohol like drowsiness even worse so you should never consider mixing Zoloft and Alcohol together.

What to do?

What you should do is that you should never mix Zoloft and alcohol as they will alleviate the side effects of each other and if you think you have no control over your drinking then you should probably discuss it through with the doctors so they can suggest you better alternatives and also they can help you with your drinking problem if it’s going out of hand. So now you know how dangerous it is to use the combination of the Zoloft and alcohol and you know how side effects can go even worse and you will then put your own life at the risk and before you know you will be the most depressed person.

Prozac vs Zoloft

Prozac vs Zoloft : Comparison between Antidepressants

Ever wonder about what antidepressant you should take? There are many, but let’s talk about Prozac vs Zoloft. Prozac and Zoloft both are the antidepressants that are used to treat the depression as well as other conditions like the obsessive-compulsive disorder, anxiety, panic attacks etc. In all such conditions, these antidepressants are prescribed by the doctors. Prozac and Zoloft are the brand names and even though are the antidepressants have different generic drugs.

The generic drug fluoxetine goes by the brand name Prozac and the sertraline hydrochloride is another generic drug that goes by the brand name Zoloft. The end results of both of these drugs are the same but the mechanism of action of Prozac vs. Zoloft is a little different, Prozac’s generic drug is a serotonin reuptake inhibitor it inhibits the serotonin reuptake in such a way that it inhibits the serotonin transporter protein and it’s also a 5HT2C antagonist while the sertraline inhibits the serotonin reuptake by inhibiting the 5HT1A receptor.

Serotonin is basically a chemical in our body that produces the feeling of well-being and happiness so when the serotonin is depleted in our body due to more reuptake it could result in depression, anxiety etc. So when these antidepressants are used they will increase the amount of serotonin in the body by blocking its reuptake and this is how they will help with your mood, good appetite and also balance your sleep.

Depression is a very dangerous disorder and it can have a very negative impact on a person’s life and this is why this disorder must be addressed and medications should be taken as prescribed to reduce and completely eliminate the depression and anxiety from your life.

Features of Prozac and Zoloft

Features of Prozac vs Zoloft will help us understand better which drug is better than the other one and whether your medications need switching or not b the prescriber. Prozac and Zoloft bot is used for the treatment of the obsessive-compulsive disorder OCD and the panic disorder while Prozac only is used for the Bulimia nervosa which is the eating disorder in which the frequent episodes of the binge eating followed by the episodes of trying to lose weight by inducing vomiting.

obsessive compulsive disorder OCD

On the other hand, Zoloft is only used for the post-traumatic stress disorder, premenstrual dysphoric disorder (sudden changes in the mood before menstruation), social anxiety disorder or social phobia. These medications are also used for some other sleeping and eating disorders but these are just some of the off-label uses and these off-label uses are those uses for which the drug can be prescribed by the doctor but it’s not the use of the drug was approved by the FDA.

Dosing differences between these two

Prozac was prescribed in the children below 7 years for Obsessive-compulsive disorder and for the rest of the purposes it is prescribed in the adults only and Zoloft is prescribed in the children below 6 years for the OCD and for the other reasons in adults only. Prozac comes in the form of oral capsules of 10mg, 20mg, 40mg and 90mg only Zoloft comes in the form of oral capsules of 25mg, 50mg & 100mg and the oral liquid concentrate solution of 20mg/ml. the good thing that is common about both of these drugs is that patients don’t have to go through the withdrawal upon discontinuing of these medications and also they don’t have the addictive potential for the medication users and this is why people font go through the withdrawal symptoms upon discontinuation. And they both also don’t fall on the list of the controlled substances so there is no potential harm upon the use of these medications.

Side effects

All the medications that we use have some side effects too and there is no medication in the entire world that doesn’t come with a side effect. The side effects caused by both of these drugs are same but there are few side effects that vary in Prozac vs Zoloft. The common side effects that can possibly arise from the usage of these medications are

  • Nausea and vomiting,
  • Diarrhea,
  • Weight gain,
  • Weight loss,
  • Insomnia,
  • A headache,
  • Dry mouth and
  • Sexual dysfunctions like the erectile dysfunction.

Side effects of Antidepressant

So these were some of the common side effects while the side effects that we observe in the Prozac vs Zoloft are that Zoloft is most likely to be the reason of diarrhoea than the Prozac so when the patient is undergoing many problems the medical practitioner upon other factors consideration can think about switching to Prozac. Similarly, Prozac versus Zoloft is most likely to be the reason for the dry mouth and the sleep disturbance so in such situations consider switching to the Zoloft to provide the patients maximum comfort. Suicidal thoughts can also initiate in the head of both these substance users between treatments so care should be given to them.

Drug interactions

Drug-drug interactions are a really worse thing so the medical practitioners should check the current medication history of the patient and void prescribing medicines that have a possible interaction with any of the previous medications. The drug-drug interaction of these drugs are with

  • Monoamine oxidase inhibitor,
  • Methylene blue injection,
  • Pimozide,
  • Linezolid

So make sure to inform the practitioner about your current medications in use. Both of these drugs are also contraindicated in the pregnancy and the breastfeeding stage.

Price variable

The price of both Prozac vs Zoloft varies even though they are used for the same purpose and the price difference is in such a way that the monthly supply of the Prozac is almost $100 more expensive as compared to the Zoloft so when it comes to the pricing Zoloft is better than the Prozac because it is in within the reach of all the classes of society.

Prozac vs Zoloft

Now coming to the final review the Prozac vs Zoloft are better than each other when we are considering only in certain aspects and to check the efficacy of both of them what you need to do is that you can read the reviews of the patients that are already using these medications which will help you to make a better judgment in Prozac vs Zoloft.

Humalog Vs Novolog

Humalog Vs Novolog – How Humalog and Novolog are different

Let’s talk about Humalog vs Novolog for Diabetes. As You know, Diabetes is one of the disorders of the today’s world that cannot be treated permanently but still thankfully new innovations came up in the past century to at least keep it in control and keep it from interfering the lives of the people. Insulin is the only thing that attempts to normalize the life of a person suffering from diabetes and it is no doubt the best the science has done for the control of diabetes.

Insulin is of different types and these types are bad upon their release mechanism and some other factors related to diabetes. Some of the insulin are immediate acting ones while some of them have long effects for almost periods of several hours so you don’t have to go through injecting yourself with insulin again and again but they are prescribed to you by your doctor based on your condition and your medical history upon the control of your blood glucose levels.

Among these types of the insulin, there are these two insulin Humalog and Novolog which are the brand names of two different types of insulin. The Humalog is the brand name of the insulin Lispro and the Novolog is the brand name for the insulin Aspart. Both of this insulin is used for the type 1 and type 2 diabetes.

Introduction to Humalog and Novolog

The Humalog and Novolog are both the same type of insulin because both of these are the rapid-acting insulin but still, both of this insulins are quite different from each other and you can understand these differences only when you see the comparison of Humalog vs Novolog. By rapid-acting, it means that both of these insulin work quicker than the other type of the insulin and when the rapid action is required for the patients that doctors prescribe these type of insulin.

Types of Insulin

But by being rapid acting it doesn’t mean that both of them have exactly same actions and what are the basic differences you will realize in the further Humalog vs Novolog discussion. Before going further into the Humalog vs Novolog discussion we should go into detail about what exactly is insulin because it will help us understand it better than anything else. Insulin is prepared in the laboratory with the help of genetic engineering and it is then injected into the subcutaneous layer of the skin which is just below the fat layer of skin.

Since in diabetes our body fails to produce the insulin so we can inject Humalog or Novolog and other such insulins and the type that your doctor prescribes is according to your body needs.

Humalog and Novolog comparison

We can only understand the Humalog vs Novolog differences when we compare both of these insulins but the thing is that these insulins are more alike than different so it’s hard to decide which one is better than the other one but on few basis, each one is for sure superior to the other one.

The similar factors about these insulins are that both of them are not available as it is in their generic form and also they are used for both type 1 and type 2 diabetes and both of them come in the form of solution for injection. The length of treatment for both of them is long term which is similar to almost any type of the drug that is used in diabetes. The storage conditions for both of them is also similar just like for any other insulin. Now coming toward the points that are different between the Humalog vs. Novolog are that the generic product in case of Humalog is the insulin Lispro and in the case of Novolog is the insulin Aspart. The other difference between them is the type of packing and application material they come in.

  • Humalog s available in 3ml cartridges, 3ml vials, 10ml vials and 3ml prefilled Kwikpen
  • While Novolog comes in 3ml FlexPen, 3ml FlexTouch, 3ml Penfill cartridges and 10ml vials.

So these were the basic similarities and the difference between the Humalog vs Novolog.

How these Humalog and Novolog are different from other insulins?

How Humalog and Novolog versus other insulins are different or what is rapid action? Well, the simple answer to this question is that Humalog and Novolog have the rapid action as compared to the long and intermediate-acting insulins. Going more into detail of rapid action you must know that they last in the body for 2 to 4 hours and achieve the peak level in just an hour. So when the peak action is required urgently then raid acting insulins like Humalog and Novolog are used.

The prescribing of Humalog vs Novolog depends upon the medical practitioner’s preference and the patient’s trust in a specific brand name.  With rapid action insulin, you should monitor the patient’s blood glucose level regularly to avoid hypoglycemia. Usually, doctors prescribe this rapid-acting in combination with the long-acting insulins.

Humalog vs Novolog

Humalog vs Novolog even though being the rapid-acting ones are quite different from each other. Novolog can be used by the patients having type 1 and type 2 diabetes while Humalog can be used by the patients suffering from the type 1 diabetes.

Novolog can be used in children above 2 years while Humalog can be used by the patients that are above the age of 3 years only. Novolog is quicker than the Humalog that makes it better than Humalog too. Humalog should be taken 15 minutes before taking the mean and Novolog should be used 5 minutes before taking a meal. Another important Humalog vs Novolog factor is that Novolog can be diluted if the lower dose is required while Humalog can’t be.

The drug costs in both the cases are same so there is no price comparison of Humalog vs. Novolog. So you can discuss it through with your doctor if you feel like switching from Humalog to Novolog or from Novolog to the Humalog and to make a better decision you should explain to the doctor all the details of your condition.

Weber Test

Weber Test and Rinne Test and Their Applications

Weber test is one of the most important medical tests when it comes to the hearing condition. This test is performed to check the unilateral conductive hearing loss. Incapability of any type is really unbearable for the person who is going through it but we anything that can make that incapability bearable would be a blessing for the person who is suffering. In the past time these things were not even able to be detected at the early stages so it can be taken control of but now the technology has emerged more than you can imagine and now if you feel such a thing that you might lose your basic senses you can have it detected at early stages and the cause of that disabilities could find out before it is too late., In such respect, the hearing loss can be detected by different types of hearing loss tests and these test are very important to detect the hearing loss at the early stages so this condition could be prevented from worsening.

Types of hearing tests

Hearing tests are very important to detect the hearing loss at the very early stages so that the condition can be avoided and these hearing tests detect the type of damage that has been caused so it could be stopped from progressing. Following are some of the type of hearing tests that you need to know about so you can have the guide in case you feel getting a hearing loss. Hearing loss could be conductive or sensorineural so these type can be indicated by following these hearing tests.

Tuning fork vibration test

The procedure of performing the tuning fork vibration test is that the fork is placed on the forehead of the person being tested and if the sound resonates on one side but not on the other side then the test indicates the patient may be suffering from the ipsilateral conductive hearing loss or contralateral sensorineural hearing loss. So by this, you can easily identify if the hearing loss is present or not.

Rinne test

What is Rinne test? Well, Rinne test is another type of the test that is used to detect the one-sided hearing loss in a person. This test is performed in such way that we compare the sound conducted by the air conduction and by the bone conduction through the mastoid. This type of test is used to identify the conductive her loss. The conductive hearing loss is the type of hearing the loss in which the ear cannot conduct the sound of waves and this type of hearing loss can be identified by this type test. In this test, the tuning fork is placed on the person’s mastoid test and the patient is supposed to tell for how long the person can hear the voice.

Rinne Test

Weber test

For those who don’t know what is Weber test? They must know that Weber test is also one of the tests for the hearing loss and this is one of the rather quick tests for the screening and this test is also used to detect the unilateral conductive hearing loss. This test is also performed to check the sensorineural hearing loss.  The sensorineural hearing loss is the type of hearing loss the cause of which is in the inner ear and the sensory organ. 90% of the hearing loss is the sensorineural type and this type of hearing loss can be permanent so it is better to check it at the early stages and this is exactly why the Weber test is the preferred one when it comes to detecting the hearing loss.

What is the Weber test?

Weber test is the type of the test that is used to detect both conductive and sensorineural hearing loss. This type of test helps doctors to determine the type of hearing loss and come up with the better treatment plans and how to stop the progress of the hearing loss. This test allows the doctor to predict how to control the hearing loss. This test works in such a way that the difference in the air conduction and bone conduction. When the conductive hearing loss occurs and the sound waves are unable to pass through the middle ear and when the sensorineural hearing loss occurs the main reason for the hearing loss is the central nervous system. Most of the times doctor use the Weber test and Rinne test to detect the type of hearing loss that has occurred.

What is Rinne test?

Rinne test is the type of the test that is used to detect the conductive type of hearing loss and this test is performed by the doctors to differentiate conductive type from the sensorineural type and hearing loss in this test is identified in such a way that the sound is resonated near the bone and differentiated from one side of the ear to the other side.

Benefits of Rinne test and Weber test

Benefits of the Rinne test and the Weber test are endless because they help identify the presence of the hearing loss and also the type of the hearing loss the treatment plan can be formed accordingly by the doctor. Following are some of the conditions that can be identified by this test because a hearing loss occurs in this test.

  • Ear infection,
  • Middle ear fluid
  • Nerve injury to ears
  • Osteosclerosis

So these are some of the conditions that can be the reason of the hearing loss and to identify hearing loss is important for this reason so that these conditions if possible could be easily treated before they get worse and become completely untreatable.

Are these tests safe?

These Rinne and Weber tests are completely safe because the method of performing the test the completely noninvasive so no pain is caused while performing these tests. So these tests are rather comfortable for the people and that is another reason why people should go for it when they need the feel too.

Getting this test done is very simple you just have to visit the local otolaryngologist so now you have all the information related to these tests you shouldn’t wait to go for it if you are having some hearing problem.